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  Indian J Med Microbiol
 

Figure 3: Mechanism of action of VMAT2 inhibitors. (a) Entry of dopamine into the synaptic vesicle for storage occurs via VMAT2. On stimulation of the neuron, the stored dopamine is released into the synaptic cleft. Dopamine that remains in the cytoplasm is degraded by monoamine oxidase. (b) VMAT2 inhibitors prevent dopamine entry into synaptic vesicle → reduce the amount of dopamine released into the synaptic cleft → lesser stimulation of the super sensitized receptors → reduction of the movements

Figure 3: Mechanism of action of VMAT2 inhibitors. (a) Entry of dopamine into the synaptic vesicle for storage occurs via VMAT2. On stimulation of the neuron, the stored dopamine is released into the synaptic cleft. Dopamine that remains in the cytoplasm is degraded by monoamine oxidase. (b) VMAT2 inhibitors prevent dopamine entry into synaptic vesicle → reduce the amount of dopamine released into the synaptic cleft → lesser stimulation of the super sensitized receptors → reduction of the movements