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Role of serotonin receptor antagonist cyproheptadine in treatment-resistant akathisia

1 Department of Psychiatry, Aarupadai Veedu Medical College and Hospital, Guwahati, India
2 Department of Physiology, AIIMS, Guwahati, India

Correspondence Address:
Vishnupriya Veeraraghavan,
Department of Psychiatry, Aarupadai Veedu Medical College and Hospital, Puducherry
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aip.aip_97_20

Akathisia is a term used for motor restlessness along with subjective feelings of tension and discomfort. It requires both subjective and objective aspects, and these behaviors are attributed to the inner feelings of tension. It is due to antipsychotic drug exposure. Treatment involves lowering the dosage of the antipsychotic medications, adding propranolol, benzodiazepines like diazepam or clonazepam, clonidine, or mirtazapine. Here, we present a case of akathisia which we found novel as the patient did not respond to the forementioned conventional methods and developed adverse effects but responded only to cyproheptadine syrup.

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