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Year : 2022  |  Volume : 6  |  Issue : 3  |  Page : 209-217

Differential profile of bipolar mood disorder, borderline personality disorder, and healthy controls using big five of personality: A meta-analysis of studies over a period of thirty years

Department of Neuroscience and Psychopathology Research, Mind GPS Institute, Kermanshah, Iran

Correspondence Address:
Dr. Saeid Komasi
Department of Neuroscience and Psychopathology Research, Mind GPS Institute, Nasr Boulevard, 404 Mokhaberat, Kermanshah
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aip.aip_121_22

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The present meta-analysis was performed to compare Five-Factor Model (FFM) personality factors between (i) patients with a bipolar mood disorder (BMD) and healthy controls (HC), (ii) patients with borderline personality disorder (BPD) and HC, and (iii) two diagnostic categories of BMD and BPD. The literature systematic search was performed on PubMed (Medline) for all articles published in English from January 1990 to June 2021 (PROSPERO-CRD42021267855). The pooled effect sizes were obtained by the standard mean differences (Cohen's d) between cases with BMD and BPD and HC using the random-effects method. Egger's test and I2 >50 were used to detect possible publication bias and heterogeneity, respectively. Due to the limited number of studies to compare FFM factors between these two diagnostic categories, we compared the standard z-scores extracted from two separate analyzes for each disorder. Eleven case-control studies were entered into the meta-analysis. The results show that there are significant differences between the two diagnostic categories and HC in all FFM factors, except openness for BMD. Based on z-scores, we found that the two diagnostic categories are different in neuroticism (BMD<BPD), extraversion (BMD>BPD), openness (BMD>BPD), and agreeableness (BMD>BPD). There was no difference between the two disorders in conscientiousness (P= 0.279). Our results suggest that profiles of personality factors distinguish BMD and BPD from HC and each other. Except for the conscientiousness factor, in other factors, BPD shows a greater tendency toward general personality psychopathology.

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